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MDL 100907

CAS No. 139290-65-6

MDL 100907 ( MDL-100907;MDL100907;Volinanserin )

Catalog No. M11635 CAS No. 139290-65-6

A potent, selective 5-HT2A receptor antagonist with Ki of 0.36 nM, > 80-fold selectivity for 5-HT2A over other serotonergic receptors.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 114 In Stock
25MG 221 In Stock
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Biological Information

  • Product Name
    MDL 100907
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective 5-HT2A receptor antagonist with Ki of 0.36 nM, > 80-fold selectivity for 5-HT2A over other serotonergic receptors.
  • Description
    A potent, selective 5-HT2A receptor antagonist with Ki of 0.36 nM, > 80-fold selectivity for 5-HT2A over other serotonergic receptors; demonstrates a clozapine-like profile of potential antipsychotic activity with low extrapyramidal sid-effect liability, and has a superior CNS safety index.Sleep Disorder Phase 3 Discontinued
  • Synonyms
    MDL-100907;MDL100907;Volinanserin
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT Receptor
  • Research Area
    Neurological Disease
  • Indication
    Sleep Disorder

Chemical Information

  • CAS Number
    139290-65-6
  • Formula Weight
    373.46
  • Molecular Formula
    C22H28FNO3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 100 mg/mL (267.8 mM); Ethanol: 18 mg/mL (48.2 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )
  • SMILES
    O[C@@H](C1=CC=CC(OC)=C1OC)C2CCN(CCC3=CC=C(F)C=C3)CC2
  • Chemical Name
    (R)-(+)-α-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperinemethanol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ardayfio PA, et al. J Pharmacol Exp Ther. 2008 Dec;327(3):891-7.
2. Sorensen SM, et al. J Pharmacol Exp Ther. 1993 Aug;266(2):684-91.
3. Kehne JH, et al. J Pharmacol Exp Ther. 1996 May;277(2):968-81.
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