MDL 100907

CAS No. 139290-65-6

MDL 100907 ( MDL-100907;MDL100907;Volinanserin )

Catalog No. M11635 CAS No. 139290-65-6

A potent, selective 5-HT2A receptor antagonist with Ki of 0.36 nM, > 80-fold selectivity for 5-HT2A over other serotonergic receptors.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 74 In Stock
10MG 114 In Stock
25MG 221 In Stock
50MG 285 In Stock
200MG 625 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    MDL 100907
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective 5-HT2A receptor antagonist with Ki of 0.36 nM, > 80-fold selectivity for 5-HT2A over other serotonergic receptors.
  • Description
    A potent, selective 5-HT2A receptor antagonist with Ki of 0.36 nM, > 80-fold selectivity for 5-HT2A over other serotonergic receptors; demonstrates a clozapine-like profile of potential antipsychotic activity with low extrapyramidal sid-effect liability, and has a superior CNS safety index.Sleep Disorder Phase 3 Discontinued
  • Synonyms
    MDL-100907;MDL100907;Volinanserin
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT Receptor
  • Research Area
    Neurological Disease
  • Indication
    Sleep Disorder

Chemical Information

  • CAS Number
    139290-65-6
  • Formula Weight
    373.46
  • Molecular Formula
    C22H28FNO3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 100 mg/mL (267.8 mM); Ethanol: 18 mg/mL (48.2 mM) ( < 1 mg/ml refers to the product slightly soluble or insoluble )
  • SMILES
    O[C@@H](C1=CC=CC(OC)=C1OC)C2CCN(CCC3=CC=C(F)C=C3)CC2
  • Chemical Name
    (R)-(+)-α-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperinemethanol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ardayfio PA, et al. J Pharmacol Exp Ther. 2008 Dec;327(3):891-7.
2. Sorensen SM, et al. J Pharmacol Exp Ther. 1993 Aug;266(2):684-91.
3. Kehne JH, et al. J Pharmacol Exp Ther. 1996 May;277(2):968-81.
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